P002 KIR GENES AS DETERMINANTS OF INNATE RESISTANCE/SUSCEPTIBILITY TO CROHN'S DISEASE
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چکیده
منابع مشابه
Pinworm Infestation Mimicking Crohns' Disease
We here report a case of a young man who presented to his general practitioner with diarrhea. Inflammatory bowel disease was suspected and a colonoscopy showed aphthous lesions suggestive of Crohns' disease but biopsies revealed eggs of Enterobius vermicularis. When treated for this parasite, his symptoms were alleviated and a followup colonoscopy revealed a normal colon and distal ileum. Enter...
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Combinations of HLA and killer cell immunoglobulin-like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA-KIR ge...
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The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. H...
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Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were ana...
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3 tudies on the biochemical effects of mutations have given strong support to the notion that individual genes are concerned with the biosynthesis of individual proteins. In a large number of instances it has been possible to attribute the absence, or modification of an enzyme to a single gene mutation. The study of such biochemical lesions, not only in microorganisms like Neurospora and E. col...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis Supplements
سال: 2009
ISSN: 1873-9954
DOI: 10.1016/s1873-9954(09)70016-3